I am wondering, wouldn’t it be more valid to introduce stem cells from the adult bone marrow? Do you think this would affect the results considering most people who contract Covid have hematopoietic cell generation in the bone marrow? Since BM has a different microbiome and cells there have likely accumulated mutations. When you were discussing creating the immunodeficient mouse models for COVID-19 testing you mentioned that they were injected with human fetal liver stem cells to in theory create human hematopoiesis in mice. I had a quick question about the mice discussed in TWIV ep 900 (burning down the mouse). Hope you are doing well! I am a student from Caltech in Bi 115, a course on viruses and their applications to biological systems. Is that still a thing, or is it a false hope that something explains illness severity not predicted by age, health, risk factors, etc.? In 2020 I heard a lot about viral dose explaining how sick different people get from COVID. The patience and endurance of the entire TWIV team is remarkable. Hello and thank you for taking my question. What are the possible mechanisms of Covid infection relapse? How is a virus able to reinfect a person shortly after it has just been cleared? Were there any hypotheses as to why total casualties from Omicron in just an 8-week period were so much worse than 23 weeks of Delta?Ģ. I was listening to TWiV 903 and had 2 questions:ġ. My name is John Soro, I am a junior studying Biology at Caltech taking Bi 115: Viruses and Applications to Biological Systems. Quick joke-which Paul McCartney song invites in a toxin: PS-Love the show! I am same age as Vincent-born 1953.įor Kathy-our daughter just graduated from MU with her Masters in Information Technology-Go Blue! We love Ann Arbor and going to be up there in July.įor Rich-my wife can trace her ancestry back to the Gotchers-supposedly Samuel sold his 4200 acres and now the town of Austin sits on most of itĪlan, Dickson, Breanne, Amy-I got nothing. So, I am curious as to if anyone has ever studied the effects of a good workout in conjunction with an effective vaccine to stimulate antibody production? Sure seemed to be some connection there. Wednesday I have my usual elliptical workout followed by a quick one mile run and no swelling this time. So three consecutive morning workouts-three swelling events. Tuesday morning-body toning workout-shower-you guessed it! Swelling is back. She feigns interest and goes back to what she was doing. Back in the shower, and repeat! Big swelling again! I say to my wife, “I think my workout is stimulating antibody response”. Next morning no swelling and I feel fine and go out for a 4 mile run. I am proud of my response! By midday, the swelling goes down, then disappears, and I think “OK, the vaccine has done its job and now my germinal centers are resting”. In the shower I am soaping up my left arm pit (shot in left arm) and it is like “Whoa-egg sized swelling!” After the shower I show my wife and assure her this is a good reaction. Feeling no ill effects from the vaccine I took off for an hour ride of about 12 miles. I am not a health nut but I do work out every morning and Sunday is my bike ride workout. Got the shot Saturday afternoon and rested the rest of the day but felt OK and felt fine the next morning. I recently got my second booster-Pfizer-having had the original J&J and then a first Pfizer booster in November.
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